The SMIM1 gene codes for the Vel antigen. The Vel negative phenotype is caused by a homozygous 17 base pair deletion in exon 3 of the SMIM1 gene which
Anti-SMIM1. Anti-SMIM1 Antibody. small integral membrane protein 1 (Vel blood group) References (1) Recommended Applications Product Description Polyclonal Antibody against Human SMIM1 Alternative Gene Names Vel Open Datasheet. Price. $450.00. Product Number. HPA069088. Unit …
This gene produces small integral membrane protein 1, a single-pass transmembrane protein which carries the Vel antigen but whose structure and function are otherwise poorly understood. SMIM1 was tagged with an opsin-derived N-glycosylation reporter at either the N- or C-terminus and synthesized in vitro using rabbit reticulocyte lysate supplemented with canine pancreatic microsomes as a source of ER membrane. SMIM1 topology was then determined by assessing the N-glycosylation of its N- or C-terminal tags. SMIM1 encodes a 78-amino acid, single transmembrane domain (TMD) containing protein with a predicted TMD at amino acids 47 to 67. The protein was previously predicted to be a type I transmembrane protein (Storry et al., 2013) but has recently been shown to be a type II transmembrane domain protein with amino acids at positions 1 to 47 predicted to constitute the cytoplasmic domain while smim1_mouse
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2013-06-03 · Expression of the Vel antigen on SMIM1-transfected HEK293T cells confirmed that SMIM1 is the gene underlying the Vel blood group. All 24 Vel-negative individuals or those with weak Vel expression who were heterozygous for the deletion were homozygous for the major A allele of SNP rs1175550, which is present in intron 2 of the STIM1 gene and is associated with decreased SMIM1 transcript levels. SMIM1, carrier of the Vel blood group, is a tail-anchored transmembrane protein and readily forms homodimers in a cell-free system. Research output: Contribution to journal › Article 2 antibodies to SMIM1 and validated for use in 2 applications (Immunohistochemistry, Western Blot) Complete information for SMIM1 gene (protein-coding), small integral membrane protein 1 (Vel blood group), including: function, proteins, disorders, pathways, orthologs, and expression. smim1_mouse
This subsection of the 'Entry information' section provides one or more accession number(s).
034, VEL, Vel, SMIM1, protein, v1.0 (160620). 035, CD59, CD59, CD59, protein, v2.0 01-MAR-2020. 036, AUG, Augustine, SLC29A1, protein, 8th April 2019.
Tested in Western Blot (WB) applications. This antibody reacts with Human, Mouse samples. Supplied as 150 µL purified antibody (0.43 mg/mL).
The Vel blood group is associated with the SMIM1 gene, which is located in the 1p36 region of chromosome 1. This gene produces small integral membrane protein 1, a single-pass transmembrane protein which carries the Vel antigen but whose structure and function are otherwise poorly understood.
doi: 10.1016/j.febslet.2015.09.029. Epub 2015 Oct 9. The Genetic Testing Registry (GTR) provides a central location for voluntary submission of genetic test information by providers. The scope includes the test's purpose, methodology, validity, evidence of the test's usefulness, and laboratory contacts and credentials. SMIM1: Small integral membrane protein 1 (Vel blood group) SMIM11A: Small integral membrane protein 11A: SMIM10: Small integral membrane protein 10: SMIM10L1: – Det nya proteinet SMIM1 påminner intressant nog om andra molekyler som utnyttjas av malariaparasiter för att infektera människor. Det är därför möjligt att SMIM1 utgör en sedan länge sökt malariareceptor på de röda blodkropparna, säger Jill Storry.
These rare donors are essential for safe blood transfusions. SMIM1 Antibodies . View more.
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Decidual cells and the neuronal cells showed weak nuclear immunoreactivity. SMIM1 gene products (22): Antibodies (1), Custom CRISPR Plasmid (1), Proteins (1), SYBR Green Primers (2), , shRNA Products (6), siRNA Products (11) Peer-Reviewed Papers.
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smim1_mouse
This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries.
SMIM1 has 1,286 functional associations with biological entities spanning 6 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 33 datasets. Click the + buttons to view associations for SMIM1 from the datasets below.
smim1_mouse
This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries.
This product is provided as three 5 nmol vials (15 nmol) or 2x three 5 nmol vials (30 nmol) of lyophilized siRNA oligo duplexes. Each vial contains slightly different sequences t smim1 ID ZDB-GENE-081022-87 Name small integral membrane protein 1 Symbol smim1 Nomenclature History Previous Names. si:dkey-23c22.1; zgc:194254; Type protein_coding_gene Location Chr: 8 Mapping Details/Browsers Description Involved in nucleate erythrocyte development. Proteintech Anti-SMIM1 Polyclonal, Catalog # 27849-1-AP. Tested in Western Blot (WB) applications. This antibody reacts with Human, Mouse samples.
GPR75-ASB3. PPT2-EGFL8. LIMA1. SYNE2. CCDC85A. SBNO2.