In the following experiments, we evaluated the heparin-bonded Carmeda Bioactive Surface (Medtronics Cardiopulmonary, Anaheim, Calif.) in an in vitro model of extracorporeal circulation at standard-dose heparin (5 U/ml), to examine the effects of the surface treatment on activation of blood elements, and at reduced-dose heparin (1 U/ml), to determine whether surface-bound heparin would serve as an effective anticoagulant.

16. Begovac PC, Thomson RC, Fisher JL, Hughson A, Gällhagen A. Improvements in GORE-TEX vascular graft performance by Carmeda BioActive surface heparin immobilization. Eur J Vasc Endovasc Surg. 2003;25:432–437

November 2015; ASAIO journal (American Society for Artificial Internal Organs: 1992) 62(2) DOI: 10.1097/MAT Textured surface (bioactive) Another bioactive surface coating is the textured surface coating. The first application of textured surface was conducted by Bernhard et al. (1968). Decron fibrils were applied with polyurethane adhesive to a silastic bladder of an LVAD. Because of its extensive publication history, there is emphasis on the CARMEDA ® BioActive Surface (CBAS ® Heparin Surface), a widely used commercialized technology for the covalent bonding of heparin. 2021-03-29 graft surface, while the bioactive site remains free to interact with the blood to help prevent clotting.7 References 1.

Improvements in GoreTex vascular graft performance by Carmeda bioactive surface heparin immobilization. Eur J Vasc Endovasc Surg. 2003;25:432-437. Heyligers JM, Verhagen HJ, Rotmans J, et al.

The CARMEDA ® BioActive Surface is licensed to major medical device companies worldwide. Below is a selection of currently approved products featuring the CARMEDA ® BioActive Surface. Berlin Heart EXCOR ® Ventricular Assist Device GORE ® PROPATEN ® Vascular Graft GORE ® VIABAHN ® Endoprosthesis GORE ® TIGRIS ® Vascular Stent

Grafts were explanted after 2 hours in a challenging carotid shunt canine model. Cortiva™ BioActive Surface Blood Tubing Packs for Closed Chest Support. Order Number.

Structuring of surface-active macromolecules. M Hedhammar, L Scalable Synthesis of Monodisperse Bioactive Spider Silk Nanostrucutres. L Gustafsson, WN

Below is a selection of currently approved products featuring the CARMEDA ® BioActive Surface. Berlin Heart EXCOR ® Ventricular Assist Device GORE ® PROPATEN ® Vascular Graft GORE ® VIABAHN ® Endoprosthesis GORE ® VIABAHN ® VBX Balloon Expandable Endoprosthesis The following features and benefits of the CARMEDA ® BioActive Surface have been shown in published clinical studies and scientific papers:.

Heparin immobilization reduces thrombogenicity of small caliber expanded polytetrafluoroethylene grafts. To determine if treatment with covalently bound heparin (Carmeda Bioactive Surface (CBAS)) to the synthetic surface of the extracorporeal circuit (ECC) would alter the stereotypic pattern of adverse platelet alterations, 450 ml of heparinized blood (lU/ml) was recirculated at a flow rate of twice the circulating volume (L/min) for 2 hrs at 37 degrees C through either untreated (CONT,n=7) or Postoperative morbidity after cardiopulmonary bypass most commonly manifests as bleeding diatheses or pulmonary dysfunction. The pathophysiology has been attributed to the activation of cellular and humoral components of blood after contact with an artificial surface.
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Below is a selection of currently approved products featuring the CARMEDA ® BioActive Surface. Berlin Heart EXCOR ® Ventricular Assist Device GORE ® PROPATEN ® Vascular Graft GORE ® VIABAHN ® Endoprosthesis GORE ® TIGRIS ® Vascular Stent The CARMEDA ® BioActive Surface is applied to a range of medical devices in our clean room. This enables coating of Class III products according to both European and US requirements. The manufacturing infrastructure is flexible and new products can easily be integrated into the existing environment.

The first application of textured surface was conducted by Bernhard et al. (1968). Decron fibrils were applied with polyurethane adhesive to a silastic bladder of an LVAD. Because of its extensive publication history, there is emphasis on the CARMEDA ® BioActive Surface (CBAS ® Heparin Surface), a widely used commercialized technology for the covalent bonding of heparin.
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MEDTRONIC PERFUSION SYSTEMS [MEDTRONIC INC.] Affinity Fusion Oxygenator with Integrated Arterial Filter and Carmeda BioActive Surface, 2017- 12-07.

Berlin Heart EXCOR ® Ventricular Assist Device GORE ® PROPATEN ® Vascular Graft GORE ® VIABAHN ® Endoprosthesis GORE ® VIABAHN ® VBX Balloon Expandable Endoprosthesis The following features and benefits of the CARMEDA ® BioActive Surface have been shown in published clinical studies and scientific papers:.

The effects of carmeda bioactive surface on human blood components during simulated extracorporeal circulation. J Thorac Cardiovasc Surg . (1996) 111:1073–84. doi: 10.1016/S0022-5223(96)70384-7

Begovac PC, Thomson RC, Fisher JL, Hughson A, Gällhagen A. Improvements in GORE-TEX® Vascular Graft performance by Carmeda® bioactive surface heparin immobilization.European Journal of Vascular & Endovascular Surgery 2003;25(5):432-437. Lindholt JS, Gottschalksen B, Johannesen N, et al. Cortiva™ BioActive Surface Blood Tubing Packs for Closed Chest Support. Order Number. Description. CB1V97R. CCS Circuit with Continuous A-V Loop, Bridge Adaptor, Bio-Pump, Flow Probe, Affinity™ CB511 Oxygenator and Accessory Package The CARMEDA ® BioActive Surface is a heparin-based coating designed to actively reduce thrombus formation on blood contacting medical devices.

The left atrium was cannulated using a Carmeda bioactive surface cannula. Distal cannulation sites were the left common femoral artery or the aorta below the involved segment. The cannulae were connected to a BioMedicus centrifugal pump via Carmeda bioactive surface tubings and pump heads. No systemic heparin was used. Ultra-smooth, flow-optimized blood contact surfaces with Carmeda ® BioActive Surface* coating for the best possible blood compatibility Safe de-airing through a de-airing port Valves at the inflow and outflow section guarantee that the blood flows in the right direction Effect of Carmeda® BioActive Surface coating versus Trillium™ Biopassive Surface coating of the oxygenator on circulating platelet count drop during cardiopulmonary bypass David A Palanzo, Debra L Zarro, Norman J Manley, Ralph M Montesano, Michael Quinn, Barbara-Anne Elmore, Patricia A Gustafson, and Joseph M Castagna Affinity CP Centrifugal Blood Pump with Carmeda® Bioactive Surface or Balance® Biosurface.